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Testing the Addition of Immunotherapy Before Surgery for Patients with Sarcomatoid Mesothelioma

Address: 5700 S Maryland Ave, Chicago, IL 60637, USA

Phone: 877-451-7009

Mesothelioma Type:

  • Pleural: False
  • Peritoneal: False
  • Pericardial: False
  • Tunica Vaginalis: False

Type: Sarcomatoid, Biphasic

Condition: Pleural Biphasic Mesothelioma, Pleural Sarcomatoid Mesothelioma

Description: This phase II trial evaluates the safety and effectiveness of giving immunotherapy (nivolumab and ipilimumab) before surgery for controlling disease in patients with stage I-IIIa sarcomatoid mesothelioma. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving immunotherapy before surgery may be more effective at controlling disease in patients with sarcomatoid mesothelioma than giving immunotherapy alone.

Research Center: University of Chicago Medicine

Treatment Interventions: BIOLOGICAL: Nivolumab, BIOLOGICAL: Ipilimumab, PROCEDURE: Surgical Procedure, PROCEDURE: Computed Tomography, PROCEDURE: Magnetic Resonance Imaging, PROCEDURE: Positron Emission Tomography

Potential Impact: High

Clinical Trial Number: NCT05647265

Phase: Phase 2

Status: Recruiting

Website: https://clinicaltrials.gov/study/NCT05647265

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