Diagnosed with Mesothelioma? Call 877-MESOTHELIOMA or Live Chat now for a Free Legal Compensation Consultation

Mesothelioma Patients Affected by Chemotherapy-Induced Nausea May Get Relief from an Antipsychotic Drug

Chemotherapy for Mesothelioma Patients

Every year, nearly 3,000 Americans are diagnosed with some form of mesothelioma, a cancer of the lining of the lung, heart or abdomen, caused by exposure to asbestos. Mesothelioma is extremely aggressive and is one of the most difficult types of cancer to treat. An equally aggressive mesothelioma chemotherapy regimen is often prescribed to battle the cancer, but the chemo side effects from the toxic amounts of medicine used often leave patients weak and dehydrated. Now, researchers report they may have found a drug to effectively treat these chemo-induced side effects.

A team of researchers, led by oncologist and cancer researcher Steven Powell, M.D., of Sanford Health, a health system headquartered in the Dakotas, have found that an off-label use of the drug olanzapine, FDA approved for use as an anti-psychotic agent, “significantly improved nausea prevention” in patients undergoing chemotherapy treatment.

“We’ve long known the nausea and vomiting that come along with chemotherapy are a major problem and affect the quality of life of our patients,” said Dr. Powell in a July 19 University of South Dakota press release. “The findings of this study, fortunately, provide physicians with a tool to better address the needs of those they are treating for cancer.”

Vomiting (medically known as emesis) and nausea from chemotherapy treatments can significantly impact a patient’s quality of life and may even lead them to halt their mesothelioma treatment. While currently, doctors can prescribe a variety of anti-emetic medications, including aprepitant (Emend®), dolasetron (Anzemet®), granisetron (Kytril®), ondansetron (Zofran®), lorazepam (Ativan®), metoclopramide (Reglan®), to minimize the sickness, many patients are still affected with some amount of vomiting.

In the study of 380 patients, with half receiving olanzapine and the other half given a placebo, 74 percent of the olanzapine patients had no chemotherapy-induced nausea within the first 24 hours after treatment, compared to 45 percent of the placebo patients. The researchers found that the benefits of using olanzapine continued for five days after chemotherapy treatment.

In 2012, researchers at Harper Cancer Institute at Indiana University reported similar results in a study of 38 patients. Then ASCO president-elect Dr. Sandra M. Swain, a breast cancer expert, said at the time, “This is a huge advance,” and “a great step forward for quality of life for our patients.”

These findings are especially important for mesothelioma patients who are undergoing chemotherapy using the doublet or triplet standard of care of cisplatin/pemetrexed or bevacizumab with pemetrexed/cisplatin, respectively. According to the American Society of Clinical Oncology, cisplatin has a “high risk” of causing nausea and vomiting. The other two drugs have a low or minimal risk.

Use rectify capitalization: makes use of the primary funding letter write my essay for leaders of persons, firms, famous situations, time, calendar months and holiday seasons; capitalize words like new mother and daddy, while they are combined with the right identify.

Mesothelioma patients are encouraged to partner with their doctors and to provide timely feedback regarding side effects and any treatment concerns to ensure the best of quality of life while battling the cancer.

The study can be found in the July 14 issue of the New England Journal of Medicine.
http://www.nejm.org/doi/10.1056/NEJMoa1515725

Sources:

  • University of South Dakota
    http://www.usd.edu/news/2016/sanford-physician-and-usd-grad-works-on-preventing-chemotherapy-side-effects
  • write my essay
    http://buildupessay.com
  • Harper Cancer Institute at Indiana University
    http://www.mdedge.com/oncologypractice/article/54549/patient-survivor-care/olanzapine-overcomes-chemotherapy-induced
Download Your Free Mesothelioma Handbook & Treatment Guide

Free Mesothelioma Patient

& Treatment Guide

We’d like to offer you our in-depth guide, “A Patient’s Guide to Mesothelioma,” absolutely free of charge.

It contains a wealth of information and resources to help you better understand the condition, choose (and afford) appropriate treatment, and exercise your legal right to compensation.

HONcode Certified

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.

Office Location

Last Modified: March 3, 2019

Copyright 2019 MesotheliomaHelp.org
The information provided by Mesothelioma Help is not a substitute for professional medical advice, diagnosis or treatment.
Our website does not host any form of advertisement.

Mesothelioma Help Cancer Organization is sponsored by Belluck & Fox, LLP
Site by Consultwebs