Mesothelioma Help Cancer News
FDA Approved Drug For Colon Cancer May Benefit Mesothelioma Patients
A drug that the U.S. Food and Drug Administration recently approved as a first-line treatment for patients with colorectal cancer may also be effective against mesothelioma, researchers say. Mesothelioma is a cancer of the lining of the chest and abdominal cavities and is closely linked to inhaling asbestos fibers.
Mesothelioma often resists standard treatments including the powerful chemotherapy drugs pemetrexed and cisplatin. Researchers in the United States and other countries continue seeking more effective therapies and ways to diagnose mesothelioma earlier when it is more treatable.
One signal that may alert doctors and medical researchers to the presence of mesothelioma at an early stage is epidermal growth factor receptor, a molecule that is overexpressed in many forms of cancer including mesothelioma, colorectal, breast and lung cancers.
The drug cetuximab, an anti-body, interferes with the function of EGFR and induces the death of cancer cells. Its effectiveness in treating certain types of colorectal cancer led the FDA to approve it as a first-line treatment in July. But cetuximab has not been well researched as a treatment for mesothelioma.
In a new study published online in August in the International Journal of Oncology, Japanese researchers report encouraging preliminary results suggesting that cetuximab may be an alternative therapy for patients who don’t respond to standard treatments. The researchers tested the effectiveness of cetuximab at arresting tumors on five lines of malignant pleural mesothelioma cells implanted into lab mice. They observed that cetuximab significantly impeded tumor growth and when applied directly to the chest cavity also improved the survival of the cancer-stricken mice.
The researchers concluded that the results “underscore the promising potential of cetuximab as a new class of therapeutic agent for use against malignant pleural mesothelioma.”
Approximately 2500 to 3000 Americans are diagnosed with mesothelioma each year. Most people diagnosed with mesothelioma are retired workers and veterans who were exposed to asbestos in a workplace or during military service decades ago. The most common form of the cancer is malignant pleural mesothelioma. Disease symptoms typically take 20 years to 50 years to appear.
Mesothelioma is as yet incurable, but there are treatment options including chemotherapy, radiation and surgery if the disease is diagnosed at an early stage.
Know more about mesothelioma and how you can deal with it.
More Hospitals Offer Mesothelioma Patients Palliative Care Options
Palliative care has been gaining momentum in the medical community as a critical step for many terminally ill patients. For mesothelioma patients in the advanced stage of their cancer, turning to palliative care, which focuses on relieving symptoms and keeping the patient comfortable, offers them an opportunity to spend more time with their loved ones during their end of life.
Mesothelioma is one of the most aggressive and deadliest forms of cancer, with limited treatment options. Symptoms may not appear until up to 50 years after initial exposure to asbestos, the only known cause of the disease. However, once symptoms become apparent, mesothelioma may rapidly progress to cause life-threatening complications. The prognosis for mesothelioma patients is grim with the average survival time varying from 4 – 18 months after diagnosis.
Now, according to a new study from the Center to Advance Palliative Care (CAPC), mesothelioma patients may have more palliative care options available to them. CAPC reports the number of U.S. hospitals with palliative care teams increased for the 10th consecutive year. In 2010, there were 1,635 palliative care teams in hospitals in the United States, for an increase of 4.3% over 2009. CAPC reports palliative care has been one of the fastest growing trends in health care over the last ten years, growing nearly 150% since 2000.
66% of American hospitals now have palliative care teams. Hospitals in the northeast region of the U.S. have the highest percentage at 75.8%. The southern region of the U.S. offers the fewest palliative care options with just 52.7% of the hospitals reporting palliative care teams.
CAPC attributes the growth of palliative care “to the increasing number of Americans living with serious and chronic illnesses and to the caregiving realities faced by their families.”
In a separate study, Massachusetts General Hospital researchers attributed palliative care to increased survival rate among advanced lung cancer patients. The researchers cited improved mood and quality of life, as well as appropriate end-of-life care, for the improved survival rates.
MGH employs palliative care teams consisting of physicians, nurses, social workers and chaplains trained to help patients and their families facing terminal illness cope with the psychological and spiritual aspects of their disease, as well as managing symptoms.
Childhood Exposure to Asbestos Increases Disease Risk Broadly, Including Mesothelioma
Australian researchers offer additional evidence that exposure to asbestos early in life may lead to a variety of serious health issues in addition to mesothelioma and lung cancer.
A new study, published in the American Journal of Industrial Medicine, reports that adults who were exposed to crocidolite asbestos in early childhood have an elevated risk of a range of cancers and heart disease. All forms of asbestos cause cancer in humans, according to the World Health Organization. But this is the first study to investigate cancer incidence among adults exposed as children to crocidolite, also known as blue asbestos.
The researchers at Western Australia Institute for Medical Research analyzed the health data of approximately 2,500 people who grew up in Wittenoom, a now-abandoned mining town in Western Australia where crocidolite asbestos was mined for nearly 20 years.
The researchers observed that women raised in Wittenoom had a 70 to 113 times greater risk of developing mesothelioma, a cancer of the lining of the lung and abdominal cavity, than among the overall population. Men also showed an increased risk of developing mesothelioma as well as an increased risk of brain, colorectal and prostate cancer and leukemia.
The research also suggests a slightly elevated risk of heart disease. Another study from the United Kingdom also recently reported an increased risk of heart disease among those exposed to asbestos.
New York cancer researchers at Mt. Sinai Medical Center are conducting an ambitious study of thousands of people who grew up between 1950 and 1999 in Libby, Montana, then moved away. Lung function develops until a child reaches age 18. Examining the lungs of people who spent their childhoods in Libby and then left may have reveal how much damage occurs from asbestos in childhood, the New York mesothelioma researchers have said.
The federal government has declared a health emergency in Libby, where asbestos contamination was widespread from a vermiculite mine and hundreds have died from asbestos related disease.
Mesothelioma is an aggressive form of cancer and a signature disease of asbestos exposure. Approximately 2,500 to 3,000 Americans are diagnosed annually with the disease and a similar number die. The disease is incurable, though there are treatments including chemotherapy, radiation and surgery.
Most people diagnosed with mesothelioma are older workers, retired workers or veterans who were exposed to asbestos fibers in the workplace or military service. Microscopic asbestos fibers when inhaled can lodge in the lungs and remain there a lifetime causing inflammation that eventually leads to asbestos related disease.
Daily Aspirin May Reduce Cancer Deaths, American Cancer Society Says
A daily aspirin may help prevent cancer, according to American Cancer Society researchers.
A large new study, published online this month in the Journal of the National Cancer Institute, offers more evidence of a positive association between taking an aspirin and modestly lower cancer mortality. Still, questions remain about the size of the health benefit, the authors of the study say. No one should start an aspirin regimen without consulting a doctor first because even low dose aspirin does cause stomach bleeding in some patients.
American Cancer Society researchers analyzed health information from more than 100,000 predominantly elderly participants who reported taking a daily aspirin and did not have cancer at the start of the study. The researchers tracked the study participants for up to 11 years.
They found daily aspirin use was associated with a 16 percent lower overall risk of dying of cancer, among people who reported taking aspirin daily for at least five years and among those who reported shorter-term daily use.
The reduction in cancer mortality reported in the current study is notably smaller than the 37 percent reduction suggested in a recent pooled analysis of 51 randomized trials published in The Lancet, a British medical journal. But the large size of the current study is a strength in determining how much daily aspirin use might lower cancer mortality.
“Although recent evidence about aspirin use and cancer is encouraging, it is still premature to recommend that people start taking aspirin specifically to prevent cancer,” American Cancer Society researcher Eric J. Jacobs, Ph.D., who led the study, said in a prepared statement. “Even low dose aspirin can substantially increase the risk of serious gastrointestinal bleeding. Decisions about aspirin use should be made by balancing the risks against the benefits in the context of each individual’s medical history.”
Earlier this year, researchers at The City College of New York reported in the ACS Medicinal Chemistry Letters that they had developed a new aspirin compound that curbed the growth of 11 different types of human cancer cells in the laboratory. Some of the cancers controlled included pancreatic cancer, lung cancer and leukemia. Lung cancer and mesothelioma are cancers caused by inhaling asbestos fibers. Mesothelioma is a cancer of the lining of the chest cavity and abdominal cavity.
In the United States, approximately 2,500 to 3,000 people are diagnosed with mesothelioma each year. The disease is incurable, though there are standard treatments to manage the disease including chemotherapy, radiation and surgery.
Most people diagnosed with mesothelioma are older workers, retired workers or veterans who were exposed to asbestos fibers in the workplace or military service. Microscopic asbestos fibers when inhaled can lodge in the lungs and remain there a lifetime causing inflammation that eventually leads to asbestos related disease.
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Risk of Asbestos Exposure for Auto Mechanics of Recalled Chinese Cars
Auto mechanics and auto repair technicians have an elevated risk of developing mesothelioma, a form of cancer, because of exposure to asbestos during car repairs. A mineral fiber, asbestos is a recognized cause of cancer in humans caused by inhaling or swallowing asbestos fibers.
The use of asbestos is banned in some countries, but is still allowed in the United States for certain purposes. According to the National Cancer Institute, the automotive industry uses asbestos in vehicle brake shoes and clutches pads.
In Australia, an automotive importer recalled 23,000 Chinese-made cars this week after customs inspectors found asbestos in engine and exhaust gaskets, Australia’s consumer protection agency announced. Australia has prohibited the importation of asbestos since 2004.
According to a statement by the Australian Competition and Consumer Commission, customs and border protection officers detected asbestos in imported spare parts from China, prompting a safety investigation. Ateco Automotive, which imports cars made by Great Wall Motor Co., and Chery Automobile, ordered dealers to stop selling the affected vehicles and recalled gaskets that were distributed as spare parts.
The asbestos is bound into gaskets in the engine and exhaust system and does not present a risk to consumers using the vehicles, the consumer watchdog agency said. But consumers should not perform do-it-yourself maintenance that might disturb the gaskets, the agent warned.
“Asbestos is a prohibited hazardous substance and these engines and exhaust systems should only be worked on by qualified personnel using appropriate safety procedures,” said Della Richard, deputy chair of the Australian Competition and Consumer Commission.
While Australia now bans importation of asbestos, the widespread use of asbestos in more than 3000 products since the 1940s means that asbestos is present in many older buildings, houses and vehicles. Asbestos was used in kitchen tiles, roofing materials, and insulation around pipes and boilers. Cars sold in Australia before 2004 often had gaskets made of asbestos.
A Work Safe Australia report released last year found 660 new cases of mesothelioma were diagnosed in Australia and 551 deaths were attributed to the disease, in the most recent year of complete data.
In the United States, approximately 2,500 to 3,000 people are diagnosed with mesothelioma each year, and a similar number die of the disease annually. The disease is incurable, though there are treatments for mesothelioma including chemotherapy, radiation and surgery.
Most people diagnosed with mesothelioma are older workers, retired workers or veterans who were exposed to asbestos fibers in the workplace or military service decades ago. Microscopic asbestos fibers when inhaled can lodge in the lungs and remain there a lifetime causing inflammation that eventually leads to asbestos related disease.
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